Gong Ping
2005
Citations
0
Influential Citations
1
Citations
Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To investigate a synthetic route of 4-(3-chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline(ZD1839).Methods The target compound was synthesized through a se- ven-step procedure starting from 3-hydroxy-4-methoxybenzoic acid methyl ester.Result and conclusion The procedure developed has several advantages such as mild reaction conditions,easily obtained materials and convenient operation.The reaction steps were reduced when comparing with the literature method(nine steps)and the total yield reached 34.81%.The structure of the ZD1839 was characterized by IR, 1H-NMR and MS.