K. Rossen, J. W. Sager, Lisa Dimichele
May 5, 1997
Citations
0
Influential Citations
32
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An efficient and versatile synthesis of piperazine-2-carboxamides 5 is described. The preparation consists of a one-pot, 4-component Ugi condensation between an N-alkylethylenediamine 1 , chloroacetaldehyde ( 2 ), an isonitrile 3 and a carboxylic acid 4 .