Chada Raji Reddy, B. Latha, Kamalkishor Warudikar
Jan 7, 2016
Citations
0
Influential Citations
9
Citations
Journal
Organic & biomolecular chemistry
Abstract
The first asymmetric total synthesis of a new natural piperidine alkaloid, microcosamine A, has been accomplished from d-serine and d-methyl lactate as chiral pool starting materials. Key features of the strategy include the utility of Horner-Wadsworth-Emmons reaction, Luche reduction, intramolecular carbamate N-alkylation to form the piperidine framework and Julia-Kocienski olefination to install the triene side-chain.