Sandip R. Khobare, V. Gajare, Nagaraju Rajana
Apr 22, 2015
Citations
0
Influential Citations
5
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Total synthesis of 2,5-disubstituted piperidine alkaloids, 5-hydroxyhomopipecolic acid ( 1 ) and 5-hydroxysedamine ( 2 ) was accomplished in overall high yields with a high level of 1,4-asymmetric induction. The ring opening of α-aminobutyrolactone, subsequent 1,3-diketone synthesis and heteroannulation via cascade reaction involving debenzylation, intramolecular cyclization and imine reduction under hydrogenation condition are the key steps involved in the synthesis.