K. D. Praliev, T. Salima, O. Zhilkibaev
2005
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Journal
Pharmaceutical Chemistry Journal
Abstract
In the present work, we continue the synthetic studies based on the readily available l-methyl piperidin-4-one (I) [5]. We have already synthesized from I a series of esters of l-methyl-4-acetylpiperidin-4-ol, among which compounds were discovered with a broad spectrum of neurotropic activity [4]. To continue the search for new effective neurotropic agents in the series of 4-substituted piperidin-4-ol derivatives, and to find the influence of the char acter of the unsaturated substituents and acylating residues at C~ on the toxicity and activity of the preparations, in the present work we synthesized and studied the pharmacological properties of l-methyl-4-vinylethyhylpiperidin-4-ol (II) and its ester (III-V).