Y. Kawashima, M. Sato, Y. Hatada
Feb 25, 1990
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Chemical & pharmaceutical bulletin
Abstract
A series of 3-acylidene-4-methylazetidin-2-one derivatives bearing various substituents at the 1-position of the azetidin-2-one ring was synthesized. These compounds were evaluated for platelet aggregation inhibitory activities. Most of the compounds synthesized showed potent inhibitory activities against rabbit platelet aggregation induced by adenosine diphosphate or collagen in vitro. Structure-activity relationships are also discussed.