Zou Jiang, Chi Xiao-wei, W. Longshan
2010
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Methylα-(2-chlorophenyl)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-acetate hydrochloride,the positional isomer of clopidogrel hydrogen sulfate,was synthesized by condensation of 3-thiophenecarboxaldehyde with nitromethane,reduction with KBH_4,condensation with HCHO and cyclization to give 4,5,6,7-tetrahydrothieno[2,3- c]pyridine,which was reacted with methyl 2-bromo-2-(2-chlorophenyl) acetate.