T. Bardos, A. K. Barua, Z. Chmielewicz
Feb 1, 1965
Citations
0
Influential Citations
10
Citations
Journal
Journal of pharmaceutical sciences
Abstract
The syntheses of a series of ring-substituted ethyl [bis(1-aziridinyl)phosphinyl]-carbamates are reported. Several of these compounds showed significant tumor inhibitory activities in experimental animals, and one of them, ethyl [bis(2,2-dimethyl-1-aziridinyl)phosphinyl]carbamate (AB-132), is currently under clinical investigation as an experimental antineoplastic agent.