Liu Chun-yan, Jiang Shen-de
Jun 13, 2011
Citations
0
Influential Citations
0
Citations
Journal
Journal name not available for this finding
Abstract
Five precursors,N-(tert-butoxycarbonyl)-O-(2-mosyloxyethyl/nosyloxyethyl)-L-tyrosine methyl ester(9a,11a) and N-(tert-butoxycarbonyl)-O-(2-mosyloxyethyl/tosyloxyethyl/nosyloxyethyl)-L-tyrosine tert-butyl ester(9b,10b,11b),were designed and synthesized for O-(2-fluoroethyl)-L-tyrosine(FET) used in positron emission tomography(PET) for tumor imaging.These compounds were prepared by the esterification of methanol or transesterification of tert-butyl acetate with L-tyrosine,protection of the amine group with di-tert-butyl dicarbonate,and then nucleophilic substitution with glycol sulfonate in three steps with overall yields varied from 30% to 67%.