R. Moldovan, W. Deuther-Conrad, A. Horti
Jan 1, 2017
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Influential Citations
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Quality indicators
Journal
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Abstract
A small series of indol-3-yl-oxoacetamides was synthesized starting from the literature known N-(adamantan-1-yl)-2-(5-(furan-2-yl)-1-pentyl-1H-indol-3-yl)-2-oxoacetamide (5) by substituting the 1-pentyl-1H-indole subunit. Our preliminary biological evaluation showed that the fluorinated derivative 8 is a potent and selective CB2 ligand with Ki = 6.2 nM.