Ethan A. Englund, H. Gopi, D. Appella
Jan 22, 2004
Citations
0
Influential Citations
51
Citations
Journal
Organic letters
Abstract
[reaction: see text] An efficient and cost-effective synthesis of N(alpha)-Boc2-N(beta)-Cbz-2,3-diaminopropionic acid is reported. The synthesis starts from commercially available N(alpha)-Boc-Asp(OBn)-OH and employs a Curtius rearrangement to establish the beta-nitrogen. Proper protection of the alpha-nitrogen is essential for the success of the Curtius rearrangement.