Qi Yuejin
2010
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Journal
The Chinese Journal of Modern Applied Pharmacy
Abstract
OBJECTIVE To improve the synthesis process of 3,4,5-trimethoxyphenyl acetic acid.METHODS 3,4,5-methoxyphenyl acetic acid was synthesized from 3,4,5-trimethoxybenzaldehyde by reduction with KBH4 in water,followed by chlorination,cyanation and hydrolysis in one-pot.RESULTS The overall yield was 64.2%.The structure of 3,4,5-trimethoxyphenyl acetic acid was confirmed by 1H-NMR.CONCLUSION The synthetic process is practical and easy to be scaled up.