Z. Ling
2009
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Journal
Food and Drug
Abstract
Objective To improve the synthesis process of.mitiglinide calcium.Methods Starting from dimethyl succinate and benzaldehyde,mitiglinide calcium was obtained via seven-step reactions including Stobble condensation,hydrolyzation,separation,reduction,anhydration,condensation with cis-hexahydroisoindoline and salt formation.Results The use amount of cis-hexahydroisoindoline was reduced through the construction of chiral center,so the cost of production of mitiglinide calcium could be decreased and the total yield was 16.4%.Conclusion A simple,easily controlled and cost-saving process for the synthesis of mitiglinide calcium can be attainable for the industrial production.