Sun Shuxiang, L. Zhimin, Ren Bao-zeng
2012
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Journal
Henan Chemical Industry
Abstract
Risedronate sodium is synthesized from nicotinic acid via TsOH catalyzed esterification,condensation,Willgerodt-Kindler reaction,hydrolysis,acidification,phosphine acidification,and formation of salt.The new process is more suitable for industrial production due to solving the solidification problem in the phosphine acidification step by adding activated carbon as the dispersing agent.