Zhou Xin-jia
2014
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Journal
Journal of Nantong Vocational College
Abstract
The paper mainly discusses the process of synthesis of thifensulfuron-methyl. Through chlorination reaction we can obtain 1, 2- two chloroethyl nitrile, using acrylonitrile as raw materials. Mercaptoacetic acid is used as raw material to react with methanol methyl thioglycolate the presence of catalyst; and 1, 2- two chloroethyl nitrile, mercaptoacetic acid methyl ester in the presence of sodium methoxide cyclization of amino thiophene. By diazotization, chlorosulfonatation, ammoniatation and aminothiophene 3- amino-sulfonyl-2-methyl 3- amino-sulfonyl-2- carboxylic acid methyl ester can be obtained. After reaction with phosgene, isocyanate and mesitylene triazine condensation and treated, thifensulfuron is produced. Experimental results show that the process route reaction yield, up to(triazine total) in an amount of 96%, which is easy to handle and control and about 90% less waste.