Dmitry S. Belov, Nina K. Ratmanova, I. Andreev
Mar 2, 2015
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12
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Journal
Chemistry
Abstract
Herein we suggest an approach to oxygenated bicyclic amino acids based on an aza-Cope-Mannich rearrangement. Seven distinct amino acid scaffolds analogous to the natural products were prepared on a gram scale with precise control of stereochemistry. Successful implementation of our strategy resulted in the formal synthesis of acetylaranotin.