L. Xiuzhen, Huang Sheng-jian, Chen Xia
2009
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Propafenone hydrochloride was synthesized from phenol and acetic anhydride by esterification,Fries rearrangement,condensation with benzaldehyde and catalytic reduction to give 2′-hydroxydihydrochalcone,which was subjected to etherification with epichlorohydrin,amination with n-propylamine and HC1 salt formation with an overall yield of 25%.