R. A. Kuroyan, V. V. Sarkisyan, S. Vartanyan
Jul 1, 1983
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Journal
Chemistry of Heterocyclic Compounds
Abstract
A method for the synthesis of 2,2-dialkyl-3-oxa-7,11-diazaspiro[5.6]dodecanes was developed on the basis of 4-bromo-4-formyltetrahydropyrans. The products were alkylated at the nitrogen atom in the 11 position by means of alkyl halides and acrylic acid derivatives, and the alkoxycarbonyl groups in the side chain were reduced.