S. V. Simakov, V. Velezheva, V. Dvorkin
May 1, 1985
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The condensation of N-(2-ethoxycarbonylindol-3-yl)-N′,N′-dialkylamidines with ammonia, primary amines, and hydrazines has given a series of 4-oxopyrimido[5,4-b] indoles which have been converted into the 4-chloro and then into the 4-methoxy, 4-dialkylamino, and 4-mercapto derivatives. 2,4-Dioxopyrimido[5,4-b]indoles have been synthesized by the successive action of chloroformic ester and then methylamine, hydrazine, or ethylhydrazine on 3-amino-2-ethoxycarbonylindoles differing by their substituents in position 5.