Jae-chul Jung, Seikwan Oh, Won-Ki Kim
Jul 1, 2003
Citations
0
Influential Citations
8
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A variety of 4-substituted quinolin-2(1H)-ones were prepared and evaluated for N-methyl-D-aspar-tate (NMDA) receptor binding site activity and their abilities to inhibit neurotoxicity. The 4-(2-car-bethoxyethanamino)-7-chloro-3-nitroquinolin-2(1H)-one (9b) exhibited favorable NMDA receptor binding site activity and 7-chloro-4-(benzylamino)-3-nitroquinolin-2(1H)-one (9c) showed the most potent neurotoxicity among them. The synthetic strategies involve the use of well known keto ester condensation and reductive ring cyclization of intermediates (2a-d) to afford 4-substituted quinolin-2(1H)-ones.