R. G. Melik-Ogandzhanyan, V. E. Khachatryan, S. G. Israelyan
Mar 1, 1989
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Journal
Pharmaceutical Chemistry Journal
Abstract
In a lengthy study searching for new biologically-active compounds in the N-benzyluracil series [i, 6, 7], we undertook the synthesis of 6-substituted N1-(3-R-4-methoxybenzyl)-N 3methyluracils (la-c, lla-e, and Ilia-d). The choice of these compounds was directed by the fact that some of our earlier-synthesized N-benzyluracils showed significant antitumor activity [i, 6] and N-sulfonylphenyluracil possessed antibacterial activity [5]. Further, information is available in the literature on the antiviral, cytostatic and sedative activity of 1,3,5-trialkyl-6-chlorouracil [I0].