M. Bodanszky, J. Tolle, J. Seto
Nov 1, 1980
Citations
0
Influential Citations
7
Citations
Journal
Journal of medicinal chemistry
Abstract
Condensation of (tert-butyloxycarbonyl)tocinoic acid with L-prolyl-L-tryptophylglycinamide produced the Boc derivative of a nonapeptide (disulfide) which on deprotection afforded [8-L-tryptophan]oxytocin. In assays on the rat uterus in vitro and in vivo the new analogue acts as both an agonist and an antagonist. The duration of both actions is prolonged.