Y. Shealy, C. A. Krauth, L. B. Holum
1968
Citations
0
Influential Citations
27
Citations
Journal
Journal of pharmaceutical sciences
Abstract
The antileukemic agent 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4 (or 5)-carboxamide (II, NSC-82196) is an unstable compound that is easily convertible to an isomeric transformation product. By taking appropriate precautions, however, the triazene may be prepared in good yield, with very little of the transformation product as contaminant, and may be stored for long periods at low temperatures. The quality of specimens of II may be estimated from its infrared spectrum and that of its transformation product.