A. Bertolini, M. Castelli, F. Borella
Feb 1, 1989
Citations
0
Influential Citations
2
Citations
Journal
Bollettino chimico farmaceutico
Abstract
The synthesis of 1-methyl-2-[(4-aminophenyl)sulfonyl] amino-5-nitroimidazole 5 is described. The new sulfonamide 5 shows a good activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria. Compound 5 is well absorbed in rats after oral administration but the plasma levels are inferior to those of sulfadiazine and sulfamethoxazole.