Hang De-y
2013
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Journal
Fine chemicals
Abstract
Using 1-bromo-3-fluorobenzene,4-bromobenzonitrile,1-(trans-4-propylcyclohexyl)-1-chloromethane as starting materials,2,6-difluoro-4-{ 3-fluoro-4'-[1-methyl-2-(4-propylcyclohexyl)-ethyl]-biphenyl} phenyl difluoromethoxy-3,4,5-trifluorobenzene was synthesized by a method consisting of seven steps,including Grignard reaction,Suzuki reaction,Witting reaction,hydrogenation reaction,etc.The reaction solvent of Grignard reagent and 4-bromobenzonitrile was xylene,and the optimum reaction time of lithiation reaction was 2 h. The overall yield was about 30% and the purity reached 99. 7%(GC)(mp: 82. 97 ~85. 04 ℃). The addition of the compound into the basic formula of liquid crystal can improve the birefringence(Δn) and reduce the threshold voltage(Vth).