T. Wada, A. Kobori, S. Kawahara
Sep 17, 1998
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Oligodeoxyribonucleotides containing 4-N-acetyl-2′-deoxycytidines (ac4dC) were synthesized by the H-phosphonate method. Thymidine 3′-O-(3,4-dichloro)phthalate bound to a solid support was employed as the starting material for the solid-phase synthesis. The (3,4-dichloro)phthaloyl (DCP) linker was found to be cleaved by treatment with 10% DBU in CH3CN for 5 min without loss of the 4-N-acetyl group of 2′-deoxycytidine. The thermal stability of the duplexes containing ac4dC was investigated.