B. Borkowski, Z. Kolodynska, A. Naciaźek-Wieniawska
1976
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Journal
Polish journal of pharmacology and pharmacy
Abstract
4,6-Dimethoxy-5-hydroxyphthalide 2 was obtained on three routes: by selective demethylation of 4,5,6-trimethoxyphthalide and by the action of formaldehyde on either syringic acid or acetylsyringic acid. Pharmacological tests carried out on rats showed that the product significantly increased bile excretion, its activity being five times higher than those of dehydrocholic acid.