S. Saeed, N. Rashid, P. Jones
2011
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0
Influential Citations
21
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Journal
Journal of Heterocyclic Chemistry
Abstract
A series of new N-Substituted-N′-(4,6-dimethylpyrimidin-2-yl)-thiourea derivatives (3a, 3b, 3c, 3d) and related fused heterocyclic compounds (4a, 4b, 4c, 4d) were synthesized using tetrabutylammonium bromide as phase transfer catalyst (PTC). N-[(2E)-5,7-dimethyl-2H-[1,2,4] thiadiazolo [2,3-a] pyrimidin-2-ylidene] derivatives (4a, 4b, 4c, 4d) were prepared by oxidative cyclization of 3a, 3b, 3c, 3d. The structures of these novel compounds were characterized by IR, 1H NMR, 13C NMR, mass spectrometry, and the elemental analysis. The crystal structures were determined from single crystal X-ray diffraction data. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compounds 3d and 3a exhibited the greatest antimicrobial activity. J. Heterocyclic Chem., 2011.