N. I. Shramm, M. E. Konshin
Jun 18, 1985
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The reaction of 2-arylamno-6-methylnicotinonitriles with acetic anhydride or benzoyl chloride gives N-acyl-2-arylamino-6-methylnicotinonitriles. Upon treatment with hydrogen chloride in anhydrous ethanol, these products are converted to 2-substituted 1-aryl-1,4-dihydro-7-methyl-4-oxopyrido[2,3-d]pyrimidines. Heating amides of 2-aryl-amino-6-methylnicotinic acids or 1-aryl-2,7-dimethyl-1,4-dihydro-4-oxopyrido[2,3-d]-pyrimidines at reflux with acetic anhydride in the presence of anhydrous sodium acetate gives 1-aryl-2-acetonyl-7-methyl-1,4-dihydro-4-oxopyrido[2,3-d]pyrimidines.