Takanori Matsumaru, T. Sunazuka, T. Hirose
Jul 21, 2008
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron
Abstract
Abstract The first, concise total synthesis of (±)-tensyuic acids B, C, and E, using chemoselective formal S N 2′ type Grignard reactions and selective esterification, is described. In addition, the optical purity of natural (±)-tensyuic acid B was determined using Chirabite-AR. Synthetic tensyuic acids, together with their intermediate compounds, were found to possess useful bioactive properties, with some of them showing potent activity against Trypanosoma brucei brucei strain GUTat 3.1.