K. Campos, M. Journet, Sandra Lee
Jan 7, 2005
Citations
0
Influential Citations
35
Citations
Journal
The Journal of organic chemistry
Abstract
An asymmetric synthesis was developed for the production of a prostaglandin D(2) receptor antagonist for the treatment of allergic rhinitis. The stereogenic center was set using asymmetric allylic alkylation chemistry, and the core of the structure was constructed via Pd-catalyzed N-cyclization/Heck methodology. The synthesis relies on a late stage indoline oxidation which does not racemize the product.