Huang Zhi-qiang
2011
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Journal
Fine chemicals
Abstract
4,5-Bis(2-bromo-4,5-dihydroxy-benzyl)-1,2-benzenediol(Ⅵ) was synthesized from veratraldehyde(Ⅰ) by employing bromination,reduction,Friedel-Crafts alkylation and demethylation with an overall yield of 53.5%.The structure of compound Ⅵ was elucidated by spectrum techniques including 1HNMR,13CNMR and HREIMS.The inhibitory activities of compound Ⅵ and 4,5-bis(2-bromo-4,5-dimethoxy-benzyl)-1,2-dimethoxybenzene(Ⅴ) against the protein tyrosine phosphatase 1B(PTP1B) were tested by the colorimetric assay.The inhibition rates of compound Ⅴ and Ⅵ against PTP1B were 25.08% and 79.48% at 20 mg/L,respectively,which indicated that compound Ⅵ was a potential therapeutic agent for the treatment of type 2 diabetes mellitus.