Anis Romdhane, H. Jannet
May 1, 2017
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0
Influential Citations
20
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Journal
Arabian Journal of Chemistry
Abstract
Abstract Various 2-amino-4 H -pyran-3-carbonitriles 1 and 2 were successfully synthesized, via a one-pot three-component condensation reaction of arylaldehyde and malononitrile with methyl acetoacetate and 8-hydroxyquinoline, respectively in moderate yields. These key intermediates 1 and 2 undergo rapid condensation with formic acid and acetic anhydride to give, respectively the corresponding pyranes 3 – 6 and pyranopyrimidinones 7 and 8 . All the synthesized compounds were completely characterized by 1 H NMR, 13 C NMR, IR and ES-HRMS.