J. Quiroga, B. Insuasty, Adolfo Sánchez
Aug 1, 1992
Citations
0
Influential Citations
51
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
6-Amino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone (1) reacts in boiling DMF with α,/β-unsaturated ketones 2 yielding the pyrido[2,3-d]pyrimidine systems 5 and 6, respectively. The orientation in the addition process can be determined by nmr measurements, especially by NOE difference spectroscopy. The products do not correspond to a normal Skraup or Doebner-v. Miller synthesis.