Ji Ya-fei
2009
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Pyridoxine hydrochloride was synthesized from L-alanine,excess oxalic acid and ethanol in benzene by simultaneous esterifi cation and acylation to afford ethyl N-ethoxyoxalyl-L-alaninate,which was subjected to cyclization,hydrolysis and decarboxylation to give 4-methyl-5-ethoxyoxazole,followed by Diels-Alder addition,aromatization,reduction and then HCl salt formation with an overall yield of 56%(based on L-alanine).