D. J. S. Cyr, N. Martin, B. Arndtsen
Jan 13, 2007
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0
Influential Citations
64
Citations
Journal
Organic letters
Abstract
[reaction: see text] A direct synthesis of pyrroles from imines, acid chlorides, and alkynes mediated by isocyanides is reported. This reaction proceeds with a range of each of these three substrates, providing a method to generate families of pyrroles in high yield. Mechanistic studies suggest this process proceeds via the generation of imino analogues of munchnones, which can undergo in situ coupling with alkynes to liberate isocyanate and form the pyrrole product.