Azadeh Shahriari, Kamran Amiri, A. Nikbakht
Jun 6, 2022
Citations
0
Influential Citations
4
Citations
Journal
The Journal of organic chemistry
Abstract
The synthesis of pyrrolidin-5-one-2-carboxamides 6a-p has been developed via a one-pot Ugi reaction of allenic acids, primary amines, isocyanides, and aldehydes followed by regioselective cyclization of the resultant N-substituted-2-allenamides with KOt-Bu at room temperature. The cyclization reaction was carried out through a 5-exo-dig approach, which resulted in good yields and high atom-economy under transition-metal-free and mild reaction conditions.