P. F. Keusenkothen, Michael B. Smith
1989
Citations
0
Influential Citations
28
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Ethyl S-pyroglutamate is converted to N -allylic-S C 5 -iodomethyl-2-pyrrolidinone. Facile radical cyclization on treatment with AIBN and tributyltin hydride in refluxing benzene gives good yields of the C 6 substituted pyrrolizidin-2-one with excellent diastereoselectivity.