Fule Wu, Hai-yuan Zhao, Yanli Xu
Apr 3, 2017
Citations
0
Influential Citations
24
Citations
Journal
The Journal of organic chemistry
Abstract
A simple and efficient catalyst-free synthesis of pyrrolo[1,2-a]quinoline derivatives from 2-methylquinolines, aldehydes, and alkynoates via dehydration/[3 + 2] cycloaddition has been developed. The reaction conditions are tolerant to air, and H2O is the only byproduct of this transformation, thus offering an environmentally benign process with a wide range of potential applications in organic synthesis and medicinal chemistry.