M. Bastrakov, A. Starosotnikov
Sep 1, 2019
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Journal
Russian Chemical Bulletin
Abstract
A series of 5-substituted 8-nitroisoquinolines was synthesized based on the reaction of 5-bromo-8-nitroisoquinohne with various nucleophiles. N-Alkylation products of 8-nitroisoquinolines were shown to undergo 1,3-dipolar cycloaddition to substituted alkenes and alkynes as dipolarophiles in the presence of a base to form new polyfunctional nitro-containing pyrrolo-[2,1-a]isoquinolines and their hydrogenated analogs.