S. A. Patil, B. Otter, R. Klein
Jul 1, 1994
Citations
0
Influential Citations
20
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
The synthesis of several new 4-mono- and 2,4-disubstituted pyrrolo- [2,1-f][1,2,4]triazines is described. Key 1-aminopyrrole-2-carbonitrile intermediates (3) and (15) were obtained by N-amination of the corres- ponding pyrrole-2-carboxaldehyde followed by CHO → CN conversion with either hydroxylamine-O-sulfonic acid for (3) or O-mesitylenesulfonyl- hydroxylamine for (15). Cyclization of (3) or (15) with a variety of amidine reagents or, after conversion of (3) to its corresponding amide, base-catalyzed annulation completed the synthesis of the title products