Hu Bin-bin
2012
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Journal
Fine chemicals
Abstract
3-(1H-pyrrole-2-carbonyl) propionic acids (Ⅱa ~Ⅱc) were synthesized,in the yields of 84.7% ~ 91.2%,by alkylation of methyl 3-(1H-pyrrole-2-carbonyl) aminopropionate(Ⅲ) with alkylhalides and followed by hydrolyzation.The title compounds Ⅰa ~Ⅰc,were obtained via cyclization ofthe acids Ⅱa ~Ⅱc in the presence of polyphosphoric acid and diphosphorus pentoxide,in the yields of69.1%~77.2%.The overall yields of the three-step reactions were 61.8% ~69.1%.And the α-glucosidase inhibition of the three title compounds have also been studied.