R. Hudson, A. K. Dambenieks, R. Viirre
Apr 1, 2005
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Journal
Nucleosides, Nucleotides & Nucleic Acids
Abstract
We have employed a tandem Sonogashira/annulation reaction between 5-iodocytosine derivatives and terminal alkynes to yield the fluorescent bicyclic nucleobase pyrrolcytosine. Pyrrolocytosine bearing substituents only on the pyrrole ring are conveniently synthesized from 5-iodocytosine. Water soluble pyrrolocytosines are being investigated as reporter groups in SNP analysis.