A. Al-Ahmadi, M. El-zohry
Apr 1, 1995
Citations
0
Influential Citations
9
Citations
Journal
Journal of Chemical Technology & Biotechnology
Abstract
1-Oxa-4-thiaspiro[4.4]nonan-2-one (1a) and/or 1-oxa-4-thiaspiro[4.5] decan-2-one (1b) were reacted with aniline and/or p-chloroaniline to afford the corresponding spirothiazolidinones (2a–d). Reaction of 2a–d with chalcones gave 2-(α – paracylbenzyl)-4-aryl-1-thia-4-azaspiro[4.4]nonan-3-one and 2-(α-aracylbenzyl)-4-aryl-1-thia-4-azaspiro[4.5]decan-3-one (3a–p) respectively. Compounds 3a–p were reacted with acetic anhydride and perchloric acid to yield the spiropyrano[2,3-d]thiazol[4]ium perchlorate derivatives 4a–p. The structures of the synthesized compounds were elucidated by elemental and spectroscopic (IR and 1H-NMR) analysis. All the prepared compounds were tested for their antimicrobial activities in comparison with tetracyclic as a reference compound.