N. Desai, A. Bhavsar, M. Shah
Apr 1, 2008
Citations
0
Influential Citations
16
Citations
Quality indicators
Journal
ChemInform
Abstract
Several new 2-(2-(4-chlorophenyl)acetyl)-N-arylhydrazinecarbothioamides 1, 5-(4-chlorobenzyl)-4-aryl-4H-1,2,4-triazole-3-thiols 2, 5-(4-chlorobenzyl)-N-aryl-1,3,4-thiadiazol-2-amines 3 and 5-(4-chlorobenzyl)-N-aryl-l,3,4-oxadiazol-2-amines 4 have been synthesized and screened for their antibacterial activity against gram +ve and gram -ve bacteria i.e S.aurens and E. coli. The QSAR studies of these compounds have been carried out in terms of structural and physicochemical parameters. Positive contribution of substituents present at position-2 of 2-[2-(4-chlorophenyl)acetyl]-A'-arylhydrazine carbothioamides 1 with bulkier group indicate increase in hydrophobicity or steric bulk character.