K. El-Bayouki, W. Basyouni, S. El-Din
Apr 1, 1994
Citations
0
Influential Citations
2
Citations
Journal
Archives of Pharmacal Research
Abstract
Reaction of 6-chloro-9-benzyl-8-(methylthio)purine3 with primary amines afforded, the corresponding 6-(substitutedamino)purines4a-g. The latter products when methylated with methyl iodide yielded smoothly N3-methyl purinium iodide salts5a-f rather than the probable N1-and N7-derivatives. 9-Benzyl-3-methyl-6-(methylimino)-8-(methylthio)purine8 was obtained upon treating the purinium iodide5a with alkali. Most of the synthesized compounds were screened for their antitumor activity.