Fengcheng Jia, Zhi-Wen Zhou, Cheng Xu
May 26, 2016
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Influential Citations
74
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Quality indicators
Journal
Organic letters
Abstract
A synergetic tert-butyl hydroperoxide/K3PO4-promoted oxidative cyclization has been developed for the facile synthesis of various functionalized quinazolin-4(3H)-ones from commercially available isatins and amidine hydrochlorides at room temperature. The synthetic utility of this strategy was illustrated by the convenient synthesis of tryptanthrin derivatives via a self-dimerization of isatins under the same conditions.