M. Arshad, M. A. Fernandez, E. McGarrigle
Jul 14, 2010
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Journal
Tetrahedron-asymmetry
Abstract
The epoxidation of meroquinene aldehyde with a chiral sulfur ylide as the key step in the synthesis of quinine and quinidine is described. The epoxidation reactions proceed under reagent control with high selectivity and good yield. The effect of sulfide and ylide substituents on the stereochemical outcome of the reaction is discussed.