Ji Ya-fei
2010
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Journal
Chinese Journal of Pharmaceuticals
Abstract
4-Hydroxy-3-nitroacetophenone was performed to undergo O-benzylation,bromination and reduction to give 1-(4-benzyloxy-3-nitrophenyl) -2-bromoethanol,from which (R) -1-(4-benzyloxy-3-nitrophenyl) -2-bromoethanol,the key intermediate of (R,R) -formoterol,was obtained via enzymatic resolution with an overall yield of about 25%.