Hongqing Hao
2007
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Journal
Chinese Journal of Pharmaceuticals
Abstract
(R)-2-Methylpyrrolidine was synthesized from (R)-2-(tritylamino)-propionaldehyde by Wittig-Horner reaction and catalytic hydrogenation to give (R)-5-methyl-2-oxopyrrolidine, which was subjected to reduction with borane-dimethylsulfide with an overall yield of 63%.